METHOD OF AND APPARATUS FOR VITRIFYING AQUEOUS SAMPLES

The invention relates to a method of and apparatus for vitrifying an aqueous sample. The method comprises the steps of providing a sample held by a sample carrier (3), regulating the temperature in a confined space (6) to a temperature above the ice nucleation temperature of the sample, guiding the...

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Bibliographische Detailangaben
Hauptverfasser: Knoops, Kevin, Ravelli, Raimond, Huysmans, Pascal, Premaraj, Navya
Format: Patent
Sprache:eng ; fre ; ger
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Beschreibung
Zusammenfassung:The invention relates to a method of and apparatus for vitrifying an aqueous sample. The method comprises the steps of providing a sample held by a sample carrier (3), regulating the temperature in a confined space (6) to a temperature above the ice nucleation temperature of the sample, guiding the sample through the confined space (6) containing the gas at the regulated temperature and positioning the sample in line with at least one nozzle (10) for a cryogenic liquid, which at least one nozzle (10) is located in the confined space (6) or outside the confined space (6), where the sample is maintained above the ice nucleation temperature of the sample, and vitrifying the sample by jetting a cryogenic liquid from the at least one nozzle (10) and onto the sample.