BISPECIFIC MOLECULE SPECIFICALLY BINDING TO B7-H3 AND TGF? AND USES THEREOF

BISPECIFIC MOLECULE SPECIFICALLY BINDING TO B7-H3 AND TGF? AND USES THEREOF

The present invention relates to a bispecific molecule including: B7-H3 antibody or antigen-binding fragment thereof; and a TGFβ binding portion bound thereto, more particularly, to a bispecific molecule which is bispecifically bound to B7-H3 and TGFβ and thus can be utilized as an immune checkpoint...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LEE, Jung Wook, PARK, Dong Woon, LEE, Jung Eun, JUNG, Byung Hun
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to a bispecific molecule including: B7-H3 antibody or antigen-binding fragment thereof; and a TGFβ binding portion bound thereto, more particularly, to a bispecific molecule which is bispecifically bound to B7-H3 and TGFβ and thus can be utilized as an immune checkpoint inhibitor for various diseases including cancer.