INHIBITORS OF NLRP3
The present invention relates to novel compounds of Formulae I-XI: wherein each A, A′, Q, Q′, W, Rw, Y, and Z, and -- are as defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical c...
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| creator | BEJCEK, Lauren HOSSEYNI, Seyedmorteza SYDORENKO, Nadiya PILLAI, Meenu HUARTE, Eduardo ZHANG, Nanjing GONG, Hua Handoko LI, Jing BARRAZA, Scott, J WOLL, Matthew, G ALAM, Rauful PARKER, Erica, N ZHANG, Xiaoyan GILBERT, Bradley, B NIEDERER, Kyle ZHENG, Tianyi TURPOFF, Anthony JEON, Woohyung LIU, Yao ZHANG, Yan RASTELLI, Ettore |
| description | The present invention relates to novel compounds of Formulae I-XI: wherein each A, A′, Q, Q′, W, Rw, Y, and Z, and -- are as defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3. |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | INHIBITORS OF NLRP3 |
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