INHIBITORS OF NLRP3

The present invention relates to novel compounds of Formulae I-XI: wherein each A, A′, Q, Q′, W, Rw, Y, and Z, and -- are as defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical c...

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Bibliographische Detailangaben
Hauptverfasser:	BEJCEK, Lauren, HOSSEYNI, Seyedmorteza, SYDORENKO, Nadiya, PILLAI, Meenu, HUARTE, Eduardo, ZHANG, Nanjing, GONG, Hua, Handoko, LI, Jing, BARRAZA, Scott, J, WOLL, Matthew, G, ALAM, Rauful, PARKER, Erica, N, ZHANG, Xiaoyan, GILBERT, Bradley, B, NIEDERER, Kyle, ZHENG, Tianyi, TURPOFF, Anthony, JEON, Woohyung, LIU, Yao, ZHANG, Yan, RASTELLI, Ettore
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to novel compounds of Formulae I-XI: wherein each A, A′, Q, Q′, W, Rw, Y, and Z, and -- are as defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.