INHIBITORS OF DUX4 ACTIVITY AND THEIR USE IN THERAPY

The present invention refers to a peptide or variants thereof wherein the peptide essentially consists of:- an amino acid sequence comprised in the sequence from aa. 1 to aa. 288 of matrin 3 (MATR3) (SEQ ID NO:1), or- a variant of an amino acid sequence comprised in the sequence from aa. 1 to aa. 28...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	Ghezzi, Paola, Berardi, Andrea, Runfola, Valeria, Musco, Giovanna, Salomè, Mara, Gabellini, Davide
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention refers to a peptide or variants thereof wherein the peptide essentially consists of:- an amino acid sequence comprised in the sequence from aa. 1 to aa. 288 of matrin 3 (MATR3) (SEQ ID NO:1), or- a variant of an amino acid sequence comprised in the sequence from aa. 1 to aa. 288 of matrin 3 (MATR3),with the proviso that the peptide does not consist of the amino acid sequence from aa. 1 to aa. 287 of matrin 3 (SEQ ID NO: 17),and preferably wherein amino acid sequence is comprised in the sequence from aa. 1 to aa. 287 or from aa 2 to aa. 288 (SEQ ID NO: 18) or from aa. 2 to aa. 287 (SEQ ID NO: 19)