ALLOPREGNANOLONE ANALOGUES FOR HIV VIREMIA AND NEUROTOXICITY PROTECTION

ALLOPREGNANOLONE ANALOGUES FOR HIV VIREMIA AND NEUROTOXICITY PROTECTION

In one aspect, the disclosure relates to pregnane neurosteroid analogues of 5α-pregnan-3α-ol-20-one (3α,5α-THP). Also disclosed herein are methods of making the same, pharmaceutical compositions comprising the same, and methods of treating HIV and/or neuroHIV using the same. The pharmaceutical compo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MAHDI, Fakhri, PARIS, Jason Richard, LE, Hoang V, KHAN, Md Imdadul H
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
STEROIDS
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Beschreibung
Zusammenfassung:In one aspect, the disclosure relates to pregnane neurosteroid analogues of 5α-pregnan-3α-ol-20-one (3α,5α-THP). Also disclosed herein are methods of making the same, pharmaceutical compositions comprising the same, and methods of treating HIV and/or neuroHIV using the same. The pharmaceutical compositions can alleviate at least one symptom associated with HIV and/or neuroHIV and can be used alone or in combination with other HIV therapies including combination antiretroviral therapy (cART).