A METHOD OF DISCOVERING NOVEL ANTICANCER DRUG USING CO-ESSENTIALITY NETWORK, AND AN APPARATUS THEREOF

A METHOD OF DISCOVERING NOVEL ANTICANCER DRUG USING CO-ESSENTIALITY NETWORK, AND AN APPARATUS THEREOF

In the present disclosure, the present inventors validated the effectiveness of the co-essentiality network, constructed from the gene essentiality profile across cancer cells, as a robust platform for identifying anticancer targets. Furthermore, the co-essentiality network facilitated the drug repu...

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Bibliographische Detailangaben
Hauptverfasser: KIM, Sang Uk, LEE, Kwang Hwan, KIM, In Hae, LEE, Ju Hun
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS
PHYSICS
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Zusammenfassung:In the present disclosure, the present inventors validated the effectiveness of the co-essentiality network, constructed from the gene essentiality profile across cancer cells, as a robust platform for identifying anticancer targets. Furthermore, the co-essentiality network facilitated the drug repurposing not previously addressed by conventional molecular networks. These findings underline the value of co-essentiality networks in advancing precision oncology, offering new potential therapeutic avenues.