HYPOALLERGENIC PEANUT ALLERGENS, PRODUCTION AND USE THEREOF

HYPOALLERGENIC PEANUT ALLERGENS, PRODUCTION AND USE THEREOF

In one embodiment, the present disclosure provides hypoallergenic peanut allergens Ara h 1 or Ara h 2 variants lacking at least one epitope recognized by anti-Ara h 1 antibodies or anti-Ara h 2 antibodies, thereby having reduced or abolished antibody binding to the peanut allergen variants. These hy...

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Bibliographische Detailangaben
Hauptverfasser: OFRAN, Yanay, BREGMAN COHEN, Almog, MARCU GARBER, Orly, KORMAN, Maayan, GAT, Yair, DIAMANT, Gil, BEN DAVID, Moshe, BIRON SOREK, Zohar, NAFTALY KIROS, Si, ROSENFELD SHLAMKOVICH, Lior, CHUPRIN, Anna, ROTEM, Etai
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:In one embodiment, the present disclosure provides hypoallergenic peanut allergens Ara h 1 or Ara h 2 variants lacking at least one epitope recognized by anti-Ara h 1 antibodies or anti-Ara h 2 antibodies, thereby having reduced or abolished antibody binding to the peanut allergen variants. These hypoallergenic peanut allergen variants may be used in methods of inducing desensitization to peanuts in a subject allergic to peanuts.