SYSTEM FOR PREVENTION, MODERATION, AND/OR TREATMENT OF COGNITIVE INJURY

This disclosure describes methods and systems for preventing, moderating, and/or treating brain injury. The methods herein may include obtaining a test result reflecting a condition of a brain in the subject, determining a stimulation parameter based on the test result, and stimulating a nerve based on the stimulation parameter, wherein stimulation of the nerve assists or causes contraction of a respiratory muscle in the subject. The systems herein may include a a stimulator configured to stimulate a first nerve, wherein stimulation of the first nerve generates negative pressure in a thoracic cavity of a subject; and stimulate a second nerve, wherein stimulation of the second nerve reduces inflammation, modulates vagus nerve signaling, or reduces a level of a causing factor of a brain injury The system also includes a processor configured to induce the stimulator to stimulate the first nerve and the second nerve.