IL-2 MUTEINS FOR TREATING CANCER OR INFECTION

IL-2 MUTEINS FOR TREATING CANCER OR INFECTION

Provided herein are IL-2 muteins that bind to the IL-2 receptor β subunit but do not have measurable binding to the IL-2 receptor a subunit. Also provided are compositions, kits, methods, and uses involving such IL-2 muteins.

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Bibliographische Detailangaben
Hauptverfasser: SRIRAMAN, Venkataraman, ALVAREZ, Juan, C, RANGANATH, Sheila, H, CHENG, Alan, C, FAYAD, Ghassan, N, KIM, Peter, S, WALSH, Nicole, C, STARLING, Gary, C, HALL, Brian, E, JUAN, Veronica, M
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Provided herein are IL-2 muteins that bind to the IL-2 receptor β subunit but do not have measurable binding to the IL-2 receptor a subunit. Also provided are compositions, kits, methods, and uses involving such IL-2 muteins.