PROCESSES FOR THE PREPARATION OF ESTETROL AND INTERMEDIATES THEREOF

A process for the preparation of a compound of formula (IIa) is described where A is a silyl protecting group, in high diastereoisomeric purity and in crystalline form, comprising the crystallization of a mixture of the compound of formula (IIa) and its isomer of formula (IIb), where A is a silyl pr...

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Hauptverfasser:	LOPOPOLO, Gianfranco, FABRIS, Francesco, MERLO, Massimo, FARINELLA, Francesco, ATTOLINO, Emanuele, GAMBARIN, Luca
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY METALLURGY ORGANIC CHEMISTRY STEROIDS
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creator	LOPOPOLO, Gianfranco FABRIS, Francesco MERLO, Massimo FARINELLA, Francesco ATTOLINO, Emanuele GAMBARIN, Luca
description	A process for the preparation of a compound of formula (IIa) is described where A is a silyl protecting group, in high diastereoisomeric purity and in crystalline form, comprising the crystallization of a mixture of the compound of formula (IIa) and its isomer of formula (IIb), where A is a silyl protecting group, from an ethereal solvent. The invention also provides a process for preparing Estetrol of formula (I) in high diastereoisomeric purity, comprising the use of the compound of formula (IIa), in a crystalline form, as a starting material.
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subjects	CHEMISTRY METALLURGY ORGANIC CHEMISTRY STEROIDS
title	PROCESSES FOR THE PREPARATION OF ESTETROL AND INTERMEDIATES THEREOF
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