PROCESSES FOR THE PREPARATION OF ESTETROL AND INTERMEDIATES THEREOF

PROCESSES FOR THE PREPARATION OF ESTETROL AND INTERMEDIATES THEREOF

A process for the preparation of a compound of formula (IIa) is described where A is a silyl protecting group, in high diastereoisomeric purity and in crystalline form, comprising the crystallization of a mixture of the compound of formula (IIa) and its isomer of formula (IIb), where A is a silyl pr...

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Bibliographische Detailangaben
Hauptverfasser: LOPOPOLO, Gianfranco, FABRIS, Francesco, MERLO, Massimo, FARINELLA, Francesco, ATTOLINO, Emanuele, GAMBARIN, Luca
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Beschreibung
Zusammenfassung:A process for the preparation of a compound of formula (IIa) is described where A is a silyl protecting group, in high diastereoisomeric purity and in crystalline form, comprising the crystallization of a mixture of the compound of formula (IIa) and its isomer of formula (IIb), where A is a silyl protecting group, from an ethereal solvent. The invention also provides a process for preparing Estetrol of formula (I) in high diastereoisomeric purity, comprising the use of the compound of formula (IIa), in a crystalline form, as a starting material.