LINEAR PEPTIDES INHIBITING CK2-MEDIATED PHOSPHORYLATION AND COMPOSITIONS COMPRISING SAME

Linear peptides that inhibit phosphorylation mediated by the enzyme casein kinase 2 (CK2), which have an amino acid sequence selected from the group consisting of the sequences identified as SEQ ID NO: 45, SEQ ID NO: 49, SEQ ID NO: 50, and SEQ ID NO: 57 - SEQ ID NO: 62, as well as polypeptides compr...

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Hauptverfasser:	GUILLÉN NIETO, Gerardo, Enrique, GONZALEZ BLANCO, Sonia, PERERA NEGRIN, Yasser, BESADA PÉREZ, Vladimir, Armando, REYES ACOSTA, Osvaldo, GARAY PÉREZ, Hilda, Elisa, GONZÁLEZ LÓPEZ, Luis, Javier, MASFORROL GONZÁLEZ, Yordanka, PEREA RODRÍGUEZ, Silvio, Ernesto, CABALLERO MENÉNDEZ, Evelin
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Linear peptides that inhibit phosphorylation mediated by the enzyme casein kinase 2 (CK2), which have an amino acid sequence selected from the group consisting of the sequences identified as SEQ ID NO: 45, SEQ ID NO: 49, SEQ ID NO: 50, and SEQ ID NO: 57 - SEQ ID NO: 62, as well as polypeptides comprising said peptides and an intracellular penetrating peptide. A pharmaceutical composition comprising at least one of these linear peptides or polypeptides and a pharmaceutically acceptable excipient. The invention also discloses the use of said peptides or polypeptides for the manufacture of a drug, and a method of treating solid or liquid tumors where said drug is administered.