INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION

INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION

Sultam compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with the KEAP1-Nrf2 interaction, such as inflammatory bowel disease, including Crohn's disease and...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WEI, Jianmei, CHAI, Wenying, KUMMER, David A, VENABLE, Jennifer D, HIRST, Gavin C, MCCLURE, Kelly J, BARBAY, J. Kent, NISHIMURA, Rachel T, KREUTTER, Kevin D, SHIH, Amy Y, VENKATESAN, Hariharan
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Sultam compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with the KEAP1-Nrf2 interaction, such as inflammatory bowel disease, including Crohn's disease and ulcerative colitis.