MARKER FOR DNA DAMAGE IN PROXIMITY OF TRANSCRIBED GENOMIC LOCI AND METHODS FOR IDENTIFYING AND/OR QUANTIFYING THESE DNA DAMAGES

The present invention relates to cyclin-dependent kinase, 12, CDK12 (cyclin-dependent kinase 12), for use as a marker for DNA damage in proximity of transcribed genomic loci in a sample, and to methods for identifying and/or quantifying in a sample DNA damage events associated to actively transcribe...

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Bibliographische Detailangaben
Hauptverfasser:	CURTI, Laura, CAMPANER, Stefano
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to cyclin-dependent kinase, 12, CDK12 (cyclin-dependent kinase 12), for use as a marker for DNA damage in proximity of transcribed genomic loci in a sample, and to methods for identifying and/or quantifying in a sample DNA damage events associated to actively transcribed genomic loci, comprising detecting the CDK12 protein in proximity of the aforesaid genomic loci.