SYSTEMS AND METHODS FOR MONITORING PACKED-BED CELL CULTURE

A bioreactor system for culturing cells is provided. The system includes a cell culture vessel with an interior reservoir. an inlet and an outlet fluidly connected to the reservoir. A fluid flow path supplies fluid to the inlet and receives fluid from the outlet. and a media conditioning vessel is f...

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Bibliographische Detailangaben
Hauptverfasser: ROMEO, Lori Eileen, GORAL, Vasiliy Nikolaevich
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:A bioreactor system for culturing cells is provided. The system includes a cell culture vessel with an interior reservoir. an inlet and an outlet fluidly connected to the reservoir. A fluid flow path supplies fluid to the inlet and receives fluid from the outlet. and a media conditioning vessel is fluidly connected to the cell culture vessel. The system also includes an outlet sensor arranged at the outlet of the cell culture vessel. The outlet sensor can detect a property of cell culture media exiting the cell culture vessel via the outlet, and the bioreactor system can adjust a property of the cell culture media based on the property detected by the outlet sensor.