NON-NATURAL 5'-UNTRANSLATED REGION AND 3'-UNTRANSLATED REGION AND USE THEREOF

Provided is an isolated polynucleotide including a nucleotide sequence coding for a non-natural 5'-untranslated region (5'-UTR) and a nucleotide sequence coding for a non-natural or natural 3'-untranslated region (3'-UTR). As such, the polynucleotide increases mRNA stabilization...

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Bibliographische Detailangaben
Hauptverfasser: SHIN, Seung Hyun, LIM, Chang Gyu, OH, Euh Lim, PARK, Da Hyeon, HEO, Yong Ho, HAN, Seung Su, LEE, Jin Bong, DONG, Joo Young
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Provided is an isolated polynucleotide including a nucleotide sequence coding for a non-natural 5'-untranslated region (5'-UTR) and a nucleotide sequence coding for a non-natural or natural 3'-untranslated region (3'-UTR). As such, the polynucleotide increases mRNA stabilization and translation efficiency and thus can be used for effectively acquiring a desired polypeptide.