SAMPLE PREPARATION

Described is a disposable device for collection and processing of biological samples, particularly for the purpose of DNA and RNA analysis procedures. The device includes (a) a hollow tip comprising first and second generally cylindrical sections and having first and second openings at first and second ends of the tip, wherein the second section and second opening have a smaller diameter than the first section and first opening, and wherein the first section and first opening are configured to removably attach to a sampling instrument; and (b) a porous nib having a working surface at a first end exposed or exposable for acquiring a biological sample, a porous structure suitable for the absorption of biological sample matter thus acquired, and for the passage of liquid through the nib; and a washing surface at a second end for application of a wash fluid to the nib. Also described is the use of polyvinylpyrrolidone, chlorhexidine, or citral as functionalising agents within the porous nib to aid release of nucleic acids without inhibiting subsequent sample processing.