TREATMENT OF CONGENITAL HYPERINSULINISM WITH AVEXITIDE

TREATMENT OF CONGENITAL HYPERINSULINISM WITH AVEXITIDE

Methods of treating congenital hyperinsulinism (CHI) are provided. In particular, the present disclosure provides for treatment of CHI by administering avexitide to a subject having CHI. The provided methods can involve subcutaneously administering avexitide to a subject having CHI. In some instance...

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Bibliographische Detailangaben
1. Verfasser: CRAIG, Colleen, M
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Methods of treating congenital hyperinsulinism (CHI) are provided. In particular, the present disclosure provides for treatment of CHI by administering avexitide to a subject having CHI. The provided methods can involve subcutaneously administering avexitide to a subject having CHI. In some instances, a reduction in the glucose infusion rate (GIR) necessary to maintain euglycemia in the subject is achieved by administering avexitide to the subject. In some instances, administering avexitide reduces the hypoglycemia event rate in a subject having CHI.