THERAPEUTICALLY EFFECTIVE ORAL ADMINISTRATION OF A 2 ARYLBENZIMIDAZOLE

THERAPEUTICALLY EFFECTIVE ORAL ADMINISTRATION OF A 2 ARYLBENZIMIDAZOLE

Methods are provided for reducing neuroinflammation and/or treating a neurodegenerative disease in a subject. The methods comprise orally administering to a subject with neuroinflammation and/or a neurogenerative disease a pharmaceutical composition comprising the compound of formula (I)(TQS-168), o...

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Bibliographische Detailangaben
Hauptverfasser: HANNESTAD, Jonas, O'gara, SMITH, Steven, August, KAKKAR, Sanjay, Kumar
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Methods are provided for reducing neuroinflammation and/or treating a neurodegenerative disease in a subject. The methods comprise orally administering to a subject with neuroinflammation and/or a neurogenerative disease a pharmaceutical composition comprising the compound of formula (I)(TQS-168), or a pharmaceutically acceptable salt thereof, in amount that provides defined plasma and brain exposures of TQS-168 and/or an active metabolite following administration.