MULTIPLE FEATURE INTEGRATION WITH NEXT-GENERATION THREE-DIMENSIONAL IN SITU SEQUENCING
Provided herein are devices, methods, and systems for multiple feature integration with next-generation three-dimensional in situ sequencing of nucleic acids in cells in intact tissue. Biological samples contain many distinct types of molecular, cellular, anatomical, and experimental features. The d...
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| creator | RICHMAN, Ethan B DEISSEROTH, Karl A |
| description | Provided herein are devices, methods, and systems for multiple feature integration with next-generation three-dimensional in situ sequencing of nucleic acids in cells in intact tissue. Biological samples contain many distinct types of molecular, cellular, anatomical, and experimental features. The disclosed methods allow simultaneous interrogation of multiple distinct features of a biological sample, including RNA features, anatomical features, exogenous barcodes, or other arbitrary experimental features such as in vivo measurements, which can be combined into single experimental readouts with next-generation in situ sequencing. |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | MULTIPLE FEATURE INTEGRATION WITH NEXT-GENERATION THREE-DIMENSIONAL IN SITU SEQUENCING |
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