EXTENDED-RELEASE COMPOSITIONS OF MEXILETINE FOR ORAL ADMINISTRATION

The present invention relates to controlled-release pharmaceutical compositions of mexiletine compounds in combination with a release retardant agent, e.g., with an ion exchange resin, and the method of making and using such compositions. In a particular aspect, the invention relates to a controlled...

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Bibliographische Detailangaben
Hauptverfasser:	CHANDRAN, Sajeev, AVACHAT, Makarand Krishnakumar, BHAMARE, Shailesh, BANBALE, Hemant Bhaurao, JOSHI, Dipak Dattatray
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to controlled-release pharmaceutical compositions of mexiletine compounds in combination with a release retardant agent, e.g., with an ion exchange resin, and the method of making and using such compositions. In a particular aspect, the invention relates to a controlled release suspension of mexiletine, or a pharmaceutically acceptable salt thereof complexed with an effective amount of a pharmaceutically acceptable ion exchange resin. In particular, the invention provides a controlled-release suspension of mexiletine to be administered once a day for the treatment of myotonic disorders. Further, the present invention provides new mexiletine compound-containing compositions having improved characteristics in terms of bioavailability, dosing frequency, and patient compliance.