NOVEL TRIPLE-HELICAL POLYPEPTIDES LACKING BINDING AFFINITY FOR THE FC DOMAIN OF IMMUNOGLOBULIN AND USES THEREOF

NOVEL TRIPLE-HELICAL POLYPEPTIDES LACKING BINDING AFFINITY FOR THE FC DOMAIN OF IMMUNOGLOBULIN AND USES THEREOF

The present invention relates to the field of protein engineering and purification and relates in particular to novel polypeptides having a triple-helical structure and lacking binding affinity for the Fc domain of immunoglobulin. The invention further relates to uses of the novel non-Fc binding pol...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ZWARG, Madlen, FIEDLER, Erik, HAUPTS, Ulrich
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present invention relates to the field of protein engineering and purification and relates in particular to novel polypeptides having a triple-helical structure and lacking binding affinity for the Fc domain of immunoglobulin. The invention further relates to uses of the novel non-Fc binding polypeptides in technical applications such as affinity chromatography, as well as in therapy and diagnostics. In addition, the present invention relates to a method of reducing the binding affinity of a polypeptide having a triple-helical structure for the Fc domain of immunoglobulin.