COMPOUNDS FOR THE MANAGEMENT OF CELL STEMNESS AND INVASION IN CANCER AND RELATED DISEASES

The present invention relates to compound of general formula (I):wherein the variables take the various meanings, pharmaceutical compositions containing them and their use in medicine, particularly in cancer such as Glioblastoma. The compounds have shown to be useful in therapy as modulators of TAP7...

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Bibliographische Detailangaben
Hauptverfasser:	MARÍN VIEIRA, Maria del Carmen, MARTÍN LÓPEZ, Marta, VINUESA NAVARRO, María de los Angeles, CAÑEDO HERNÁNDEZ, María Librada, FERNÁNDEZ MEDARDE, Antonio, MARQUÉS MARTÍNEZ, Margarita M, VILLOCH FERNÁNDEZ, Javier, SÁNCHEZ LÓPEZ, José María
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to compound of general formula (I):wherein the variables take the various meanings, pharmaceutical compositions containing them and their use in medicine, particularly in cancer such as Glioblastoma. The compounds have shown to be useful in therapy as modulators of TAP73 and stemness- and invasiveness-related genes. The compounds may be isolated from the fermentation broth of a fungal strain of Chaetomium sp., or are derivatives thereof. The strain of Chaetomium sp. HT-GU-SUES-904 with accession number CECT 20840 is also claimed.