FC VARIANT WITH ENHANCED AFFINITY TO FC RECEPTORS AND IMPROVED THERMAL STABILITY

FC VARIANT WITH ENHANCED AFFINITY TO FC RECEPTORS AND IMPROVED THERMAL STABILITY

The present disclosure provides Fc domain variants, including effector-competent Fc domain variants. The present disclosure also provides nucleic acids encoding Fc domain variants and host cells for making Fc domain variants. Methods for increasing the yield of Fc domain variants, and methods of usi...

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Bibliographische Detailangaben
Hauptverfasser: LANGE, Christian, MASIERO, Alessandro, CAMERON, Béatrice, PARK, Sunghae, FOCKEN, Ingo, KATHURIA, Sagar, BENINGA, Jochen, TILLMANN, Bodo
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present disclosure provides Fc domain variants, including effector-competent Fc domain variants. The present disclosure also provides nucleic acids encoding Fc domain variants and host cells for making Fc domain variants. Methods for increasing the yield of Fc domain variants, and methods of using Fc domain variants to treat disease, are also provided.