TRIAZOLO-PYRIMIDINE ANALOGUES FOR TREATING DISEASES CONNECTED TO THE INHIBITON OF WERNER SYNDROME RECQ HELICASE (WRN)

The present invention provides a compound, or a pharmaceutically acceptable salt thereof, of formula (I):wherein R1, R2, R3, R4, R5, R26, R27, y, R, M, W, L, V, T, Y, J, K and A are as described herein, therapeutic uses of said compounds, uses of said compounds as research chemicals, a pharmaceutica...

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Bibliographische Detailangaben
Hauptverfasser:	ZHANG, Sisi, MOEBITZ, Henrik, NOCITO, Sandro, GOGNIAT, Geoffrey, GONG, Wanben, SOTO, Jessica, HOLZER, Philipp, SCHOEPFER, Joseph, ZECRI, Frédéric, BORDAS, Vincent, FUREGATI, Markus, LIMAM, Fatma, YU, Huangchao, YAO, Shuping, STRANG, Ross, HAMON, Jacques, BRUN, Jvan, SCHMIEDEBERG, Niko, DECKER, Andrea, HINRICHS, Juergen Hans-Hermann, PLATTNER, Simone
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides a compound, or a pharmaceutically acceptable salt thereof, of formula (I):wherein R1, R2, R3, R4, R5, R26, R27, y, R, M, W, L, V, T, Y, J, K and A are as described herein, therapeutic uses of said compounds, uses of said compounds as research chemicals, a pharmaceutical composition and combinations comprising said compounds, and methods for manufacturing the compounds of the invention.