HETEROARYL DIAMIDE IRE1/XBP1S ACTIVATORS

HETEROARYL DIAMIDE IRE1/XBP1S ACTIVATORS

Provided herein are compounds that activate IRE1/XBP1s, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject having a disease or disorder that may be ameliorated by increa...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WISEMAN, R. Luke, LEE, Kyunga, GUERRERO, Adrian Marco, KELLY, Jeffery W, LABAUDINIERE, Richard F, PETRASSI, Hank Michael James, TAIT, Bradley Dean
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Provided herein are compounds that activate IRE1/XBP1s, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject having a disease or disorder that may be ameliorated by increasing IRE1/XBP1s activity.