N-(HYDROXYALKYL (HETERO)ARYL) TETRAHYDROFURAN CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS

N-(HYDROXYALKYL (HETERO)ARYL) TETRAHYDROFURAN CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS

Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharm...

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Hauptverfasser: SKERRATT, Sarah, CARVALHO MEIRELES, Lidio Marx, SHAW, David Matthew, PONTILLO, Joseph, GALAN, Bhairavi, STAMOS, Dean, CHUDYK, Ewa Iwona, PULLIN, Robert, KNEGTEL, Ronald Marcellus, SCHMIDT, Yvonne, BECK, Elizabeth, Mary, ZHOU, Jinglan, NORTH, Kiri, ETXEBARRIA JARDI, Gorka, HURLEY, Dennis James, O'DONNELL, Michael Edward, HADIDA RUAH, Sara S, NEUBERT, Timothy Donald, THOMSON, Stephen Andrew, VIRANI, Anisa Nizarali, AHMAD, Nadia M, DODD, James, DURRANT, Steven John, PINDER, Joanne Louise, WRAY, Christopher
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.