TOLERANCE-INDUCING CONSTRUCTS AND COMPOSITIONS AND THEIR USE FOR THE TREATMENT OF IMMUNE DISORDERS

TOLERANCE-INDUCING CONSTRUCTS AND COMPOSITIONS AND THEIR USE FOR THE TREATMENT OF IMMUNE DISORDERS

The present disclosure relates to tolerance-inducing constructs for inducing tolerance, such as by targeting the tolerance-inducing construct to antigen presenting cells (APCs). Further disclosed are polynucleotides, vectors, host cells, pharmaceutical compositions and kits comprising said tolerance...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MYRSET, Heidi, BERSAAS, Audun Trygge Haugen, GRANUM, Stine, DILLARD, Pierre, FREDRIKSEN, Agnete Brunsvik
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure relates to tolerance-inducing constructs for inducing tolerance, such as by targeting the tolerance-inducing construct to antigen presenting cells (APCs). Further disclosed are polynucleotides, vectors, host cells, pharmaceutical compositions and kits comprising said tolerance-inducing construct. Also disclosed are tolerance-inducing constructs and compositions for use in the treatment of immune disorders, such as in the prophylactic or therapeutic treatment of autoimmune diseases, allergic disease and graft rejection.