AAV VIRION ENCODING NEUROTROPHIC FACTOR AND USES THEREOF

Provided are recombinant adeno-associated virus (rAAV) virions, methods of treating an ocular condition, pharmaceutical compositions, and other compositions and methods, in which the rAAV virion comprises a poly nucleotide encoding a neurotrophic factor, such as Nerve Growth Factor (NGF) or Glial De...

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Bibliographische Detailangaben
Hauptverfasser: NAU, Jeffrey Alan, CARLSON, Eric C
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Provided are recombinant adeno-associated virus (rAAV) virions, methods of treating an ocular condition, pharmaceutical compositions, and other compositions and methods, in which the rAAV virion comprises a poly nucleotide encoding a neurotrophic factor, such as Nerve Growth Factor (NGF) or Glial Derived Neurotrophic Factor (GDNF). Methods of treatment may include administration to the lacrimal gland.