HYPERBRANCHED POLYGLYCEROL-COATED PARTICLES AND METHODS OF MAKING AND USING THEREOF
The present invention provides particles comprising a core comprising one or more polymers; (b) a shell comprising hyperbranched polyglycerol; and (c) one or more nucleic acids, one or more peptides, or a combination thereof; wherein the one or more polymers are more hydrophobic than the hyperbranch...
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| creator | Deng, Yang Saltzman, William M Ediriwickrema, Asiri |
| description | The present invention provides particles comprising a core comprising one or more polymers; (b) a shell comprising hyperbranched polyglycerol; and (c) one or more nucleic acids, one or more peptides, or a combination thereof; wherein the one or more polymers are more hydrophobic than the hyperbranched polyglycerol; wherein the hyperbranched polyglycerol is covalently bound to the one or more polymers; wherein the hyperbranched polyglycerol at the surface of the particles comprises hydroxyl groups converted to one or more reactive functional groups selected from aldehydes, amines, oximes, O-substituted oximes, and combinations thereof; and wherein optionally the particles are modified by attachment of polyethylene glycol to the surface of the particles. |
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(b) a shell comprising hyperbranched polyglycerol; and (c) one or more nucleic acids, one or more peptides, or a combination thereof; wherein the one or more polymers are more hydrophobic than the hyperbranched polyglycerol; wherein the hyperbranched polyglycerol is covalently bound to the one or more polymers; wherein the hyperbranched polyglycerol at the surface of the particles comprises hydroxyl groups converted to one or more reactive functional groups selected from aldehydes, amines, oximes, O-substituted oximes, and combinations thereof; and wherein optionally the particles are modified by attachment of polyethylene glycol to the surface of the particles.</description><language>eng ; fre ; ger</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240306&DB=EPODOC&CC=EP&NR=4331618A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240306&DB=EPODOC&CC=EP&NR=4331618A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Deng, Yang</creatorcontrib><creatorcontrib>Saltzman, William M</creatorcontrib><creatorcontrib>Ediriwickrema, Asiri</creatorcontrib><title>HYPERBRANCHED POLYGLYCEROL-COATED PARTICLES AND METHODS OF MAKING AND USING THEREOF</title><description>The present invention provides particles comprising a core comprising one or more polymers; (b) a shell comprising hyperbranched polyglycerol; and (c) one or more nucleic acids, one or more peptides, or a combination thereof; wherein the one or more polymers are more hydrophobic than the hyperbranched polyglycerol; wherein the hyperbranched polyglycerol is covalently bound to the one or more polymers; wherein the hyperbranched polyglycerol at the surface of the particles comprises hydroxyl groups converted to one or more reactive functional groups selected from aldehydes, amines, oximes, O-substituted oximes, and combinations thereof; and wherein optionally the particles are modified by attachment of polyethylene glycol to the surface of the particles.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAj2iAxwDXIKcvRz9nB1UQjw94l094l0dg3y99F19ncMAYk5BoV4Ovu4Bis4-rko-LqGePi7BCv4uyn4Onp7-rmDRUODQawQD9cgV383HgbWtMSc4lReKM3NoODmGuLsoZtakB-fWlyQmJyal1oS7xpgYmxsaGZo4WhkTIQSALLoL3k</recordid><startdate>20240306</startdate><enddate>20240306</enddate><creator>Deng, Yang</creator><creator>Saltzman, William M</creator><creator>Ediriwickrema, Asiri</creator><scope>EVB</scope></search><sort><creationdate>20240306</creationdate><title>HYPERBRANCHED POLYGLYCEROL-COATED PARTICLES AND METHODS OF MAKING AND USING THEREOF</title><author>Deng, Yang ; 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| language | eng ; fre ; ger |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | HYPERBRANCHED POLYGLYCEROL-COATED PARTICLES AND METHODS OF MAKING AND USING THEREOF |
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