HYPERBRANCHED POLYGLYCEROL-COATED PARTICLES AND METHODS OF MAKING AND USING THEREOF

The present invention provides particles comprising a core comprising one or more polymers; (b) a shell comprising hyperbranched polyglycerol; and (c) one or more nucleic acids, one or more peptides, or a combination thereof; wherein the one or more polymers are more hydrophobic than the hyperbranched polyglycerol; wherein the hyperbranched polyglycerol is covalently bound to the one or more polymers; wherein the hyperbranched polyglycerol at the surface of the particles comprises hydroxyl groups converted to one or more reactive functional groups selected from aldehydes, amines, oximes, O-substituted oximes, and combinations thereof; and wherein optionally the particles are modified by attachment of polyethylene glycol to the surface of the particles.