MHC CLASS II T-CELL MODULATORY POLYPEPTIDES AND METHODS OF USE THEREOF

MHC CLASS II T-CELL MODULATORY POLYPEPTIDES AND METHODS OF USE THEREOF

The present disclosure provides T-cell modulatory polypeptides (TMPs) comprising an AI peptide epitope, MHC class II polypeptides, one or more immunomodulatory polypeptides, a TGF-β polypeptide, and a masking polypeptide. A TMP of the present disclosure is useful for modulating activity of a T cell....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LOW, Chee Meng, SEIDEL III, Ronald, D, CHAPARRO, Rodolfo, J
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure provides T-cell modulatory polypeptides (TMPs) comprising an AI peptide epitope, MHC class II polypeptides, one or more immunomodulatory polypeptides, a TGF-β polypeptide, and a masking polypeptide. A TMP of the present disclosure is useful for modulating activity of a T cell. Thus, the present disclosure provides compositions and methods for modulating the activity of T cells, as well as compositions and methods for treating persons who have an autoimmune disease.