BISPECIFIC MULTIFUNCTIONAL FUSION POLYPEPTIDE

The present application relates to the technical field of biomedicines, and particularly to a bispecific fusion polypeptide. The bispecific fusion polypeptide comprises an antigen-binding moiety. The antigen-binding moiety comprises a first antigen-binding moiety comprising a first polypeptide comprising a first heavy chain variable domain VH1 of a first antibody from the N terminus to the C terminus, which is operably linked to a first conjugate fragment; and a second polypeptide comprising a first light chain variable domain VL1 of the first antibody from the N terminus to the C terminus, which is operably linked to a second conjugate fragment, wherein the first conjugate fragment and the second conjugate fragment are capable of specifically binding; and the first conjugate fragment is a receptor and the second conjugate fragment is a ligand; or the first conjugate fragment is a ligand and the second conjugate fragment is a receptor.