METHODS AND SYSTEMS FOR DESIGNING PHAGE COCKTAILS

Methods and systems for designing phage therapy cocktails. A candidate phage selector module may be configured to predict lytic activity of phages using a first trained machine learning algorithm, and select candidate phages based at least in part on predicted lytic activity. A cocktail generator mo...

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Hauptverfasser: PIERINGER CASTRO, Hans, ROJAS ARACENA, Felipe Alberto, AGUILERA BARRIOS, Matías, NORAMBUENA VENEGAS, Rodrigo, TOBAR CALFUCOY, Eduardo, CIFUENTES FIGUEROA, Onix Andriet, BERMAN, Nicolás Alexis, CIFUENTES MUÑOZ, Nicolás, SABAG MATILLA, Andrea Verónica, CIFUENTES PALMA, Pablo, PIERINGER BAEZA, Christian Philip, OSSA GUERRA, Antonio Andrés
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Methods and systems for designing phage therapy cocktails. A candidate phage selector module may be configured to predict lytic activity of phages using a first trained machine learning algorithm, and select candidate phages based at least in part on predicted lytic activity. A cocktail generator module may be configured to generate a set of phage cocktails using a second trained machine learning algorithm, based at least in part on predicted lytic activity. A feedback panel module may be configured to receive feedback information associated with phage cocktails, and use the feedback information to train the first and/or second trained machine learning algorithms.