BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TREM2
The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TREM2. The invention also relates to multimeric b...
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| creator | BRENNAN, Paul STANWAY, Steven MCCRORY, Rama GOWANS, Ellen CHEN, Liuhong MEAD, Emma DI RIENZO, Donatella MURPHY, Emma SKYNNER, Michael SMITH, Tom DAVIS, John BROWN, Amy DEMYDCHUK, Yuliya RIGBY, Mike |
| description | The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TREM2. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder mediated by TREM2. |
| format | Patent |
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In particular, the invention describes peptides which bind to TREM2. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder mediated by TREM2.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240124&DB=EPODOC&CC=EP&NR=4308586A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,782,887,25571,76555</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240124&DB=EPODOC&CC=EP&NR=4308586A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BRENNAN, Paul</creatorcontrib><creatorcontrib>STANWAY, Steven</creatorcontrib><creatorcontrib>MCCRORY, Rama</creatorcontrib><creatorcontrib>GOWANS, Ellen</creatorcontrib><creatorcontrib>CHEN, Liuhong</creatorcontrib><creatorcontrib>MEAD, Emma</creatorcontrib><creatorcontrib>DI RIENZO, Donatella</creatorcontrib><creatorcontrib>MURPHY, Emma</creatorcontrib><creatorcontrib>SKYNNER, Michael</creatorcontrib><creatorcontrib>SMITH, Tom</creatorcontrib><creatorcontrib>DAVIS, John</creatorcontrib><creatorcontrib>BROWN, Amy</creatorcontrib><creatorcontrib>DEMYDCHUK, Yuliya</creatorcontrib><creatorcontrib>RIGBY, Mike</creatorcontrib><title>BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TREM2</title><description>The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. 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The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder mediated by TREM2.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB28nSOdPbxdFYIcA0I8XRxVfDxdHf0cwlWCA5wdfZ0A0q4-QcphAS5-hrxMLCmJeYUp_JCaW4GBTfXEGcP3dSC_PjU4oLE5NS81JJ41wATYwMLUwszR0NjIpQAABDGJEQ</recordid><startdate>20240124</startdate><enddate>20240124</enddate><creator>BRENNAN, Paul</creator><creator>STANWAY, Steven</creator><creator>MCCRORY, Rama</creator><creator>GOWANS, Ellen</creator><creator>CHEN, Liuhong</creator><creator>MEAD, Emma</creator><creator>DI RIENZO, Donatella</creator><creator>MURPHY, Emma</creator><creator>SKYNNER, Michael</creator><creator>SMITH, Tom</creator><creator>DAVIS, John</creator><creator>BROWN, Amy</creator><creator>DEMYDCHUK, Yuliya</creator><creator>RIGBY, Mike</creator><scope>EVB</scope></search><sort><creationdate>20240124</creationdate><title>BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TREM2</title><author>BRENNAN, Paul ; STANWAY, Steven ; MCCRORY, Rama ; GOWANS, Ellen ; CHEN, Liuhong ; MEAD, Emma ; DI RIENZO, Donatella ; MURPHY, Emma ; SKYNNER, Michael ; SMITH, Tom ; DAVIS, John ; BROWN, Amy ; DEMYDCHUK, Yuliya ; RIGBY, Mike</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP4308586A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>BRENNAN, Paul</creatorcontrib><creatorcontrib>STANWAY, Steven</creatorcontrib><creatorcontrib>MCCRORY, Rama</creatorcontrib><creatorcontrib>GOWANS, Ellen</creatorcontrib><creatorcontrib>CHEN, Liuhong</creatorcontrib><creatorcontrib>MEAD, Emma</creatorcontrib><creatorcontrib>DI RIENZO, Donatella</creatorcontrib><creatorcontrib>MURPHY, Emma</creatorcontrib><creatorcontrib>SKYNNER, Michael</creatorcontrib><creatorcontrib>SMITH, Tom</creatorcontrib><creatorcontrib>DAVIS, John</creatorcontrib><creatorcontrib>BROWN, Amy</creatorcontrib><creatorcontrib>DEMYDCHUK, Yuliya</creatorcontrib><creatorcontrib>RIGBY, Mike</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BRENNAN, Paul</au><au>STANWAY, Steven</au><au>MCCRORY, Rama</au><au>GOWANS, Ellen</au><au>CHEN, Liuhong</au><au>MEAD, Emma</au><au>DI RIENZO, Donatella</au><au>MURPHY, Emma</au><au>SKYNNER, Michael</au><au>SMITH, Tom</au><au>DAVIS, John</au><au>BROWN, Amy</au><au>DEMYDCHUK, Yuliya</au><au>RIGBY, Mike</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TREM2</title><date>2024-01-24</date><risdate>2024</risdate><abstract>The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TREM2. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder mediated by TREM2.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TREM2 |
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