BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TREM2

The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TREM2. The invention also relates to multimeric b...

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Bibliographische Detailangaben
Hauptverfasser:	BRENNAN, Paul, STANWAY, Steven, MCCRORY, Rama, GOWANS, Ellen, CHEN, Liuhong, MEAD, Emma, DI RIENZO, Donatella, MURPHY, Emma, SKYNNER, Michael, SMITH, Tom, DAVIS, John, BROWN, Amy, DEMYDCHUK, Yuliya, RIGBY, Mike
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TREM2. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder mediated by TREM2.