VARIANT OF RUMINOCOCCUS GNAVUS STRAIN-DERIVED 7-BETA-HSDH, IMPROVING CONVERSION RATE FROM 7-KETO-LCA TO URSODEOXYCHOLIC ACID, AND METHOD FOR PRODUCING URSODEOXYCHOLIC ACID BY USING SAME

VARIANT OF RUMINOCOCCUS GNAVUS STRAIN-DERIVED 7-BETA-HSDH, IMPROVING CONVERSION RATE FROM 7-KETO-LCA TO URSODEOXYCHOLIC ACID, AND METHOD FOR PRODUCING URSODEOXYCHOLIC ACID BY USING SAME

The present invention relates to a variant of (Ruminococcus gnavus strain-derived 7 beta-hydroxysteroid (7-beta-HSDH), improving a conversion rate from 7-keto lithocholic acid (7-keto-LCA) to ursodeoxycholic acid (UDCA), and a method for producing ursodeoxycholic acid by using same. In the present i...

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Bibliographische Detailangaben
Hauptverfasser: PARK, Jae Bum, JANG, Hyung Wook, SOHN, Min Jeong, KIM, So Young, MIN, Byeong Gyu
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present invention relates to a variant of (Ruminococcus gnavus strain-derived 7 beta-hydroxysteroid (7-beta-HSDH), improving a conversion rate from 7-keto lithocholic acid (7-keto-LCA) to ursodeoxycholic acid (UDCA), and a method for producing ursodeoxycholic acid by using same. In the present invention, the conversion efficiency of 7-Keto-LCA to UDCA has been improved through enzyme modification for development for variant production and recombinant protein production, and thus the present invention is expected to be widely used to improve UDCA biosynthesis and biosynthetic efficiency.