COMPOUND OR SALT THEREOF, AND ANTIBODY OBTAINED USING SAME

The present invention provides a technique that controls a bonding ratio of an antibody and a modifying group within a desired range. More specifically, the present invention provides a compound or salt thereof represented by the following formula (I):whereinX indicates a leaving group,Y indicates a...

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Bibliographische Detailangaben
Hauptverfasser: HATADA, Noriko, HIRAMA, Ryusuke, ARASHIDA, Naoko, FUJII, Tomohiro, YAMADA, Kei, MATSUDA, Yutaka
Format: Patent
Sprache:eng ; fre ; ger
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Beschreibung
Zusammenfassung:The present invention provides a technique that controls a bonding ratio of an antibody and a modifying group within a desired range. More specifically, the present invention provides a compound or salt thereof represented by the following formula (I):whereinX indicates a leaving group,Y indicates an affinity peptide having a binding region in a CH2 domain in an immunoglobulin unit comprising two heavy chains and two light chains,M indicates a trivalent group linking the carbon atom in C=O adjacent to M and the carbon atom in C=W via a main chain portion consisting of 3 to 5 carbon atoms,O indicates an oxygen atom,S indicates a sulfur atom,W indicates an oxygen atom or a sulfur atom,N3 indicates an azide group,La indicates a bond or a divalent group, andLb indicates a bond or a divalent group; and antibodies or salts thereof which can be prepared using such a compound or salt thereof.