MEANS AND METHODS FOR IMPLANTING CELLS SECRETING A THERAPEUTIC COMPOUND

A device for implantation into a mammalian host has a dialysis tube with a lumen and a dialysis membrane enclosing the lumen. The dialysis tube has an outer diameter of 20 μm to 600 μm. The dialysis membrane has a molecular weight cutoff of from 25 kDa to 150 kDa and has a material composition of at...

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Bibliographische Detailangaben
Hauptverfasser:	DIEHR, Florian, STAIB, Arnulf, LICHT, Alexander
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
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Beschreibung
Zusammenfassung:	A device for implantation into a mammalian host has a dialysis tube with a lumen and a dialysis membrane enclosing the lumen. The dialysis tube has an outer diameter of 20 μm to 600 μm. The dialysis membrane has a molecular weight cutoff of from 25 kDa to 150 kDa and has a material composition of at least one of the following: polyethersulfone, polyarylethersulfone, polyethylene, polytetrafluoroethylene, polyvinylidene fluoride, and polypropylene. A therapeutic composition is disposed within the lumen and has cells that secrete a therapeutic compound. A matrix material embeds the cells. The matrix material is one or more of alginate, collagen, fibrin, extracellular matrix material, synthetic hydrogel, and acrylate. Also disclosed are a method of producing a device for implantation, a port system, and a cell secreting a therapeutic compound for use in treating disease by implantation of the cells in a device for implantation.