PROCESS FOR BIOCONJUGATE PRODUCTION

The present invention relates to a process for the production of purified O-polysaccharide-Exoprotein A (O-EPA) bioconjugates. In particular, the process comprises a purification of said bioconjugate comprising the steps of a first anion exchange chromatography prior to a hydroxyapatite chromatograp...

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Bibliographische Detailangaben
Hauptverfasser:	KAESER, Matthias Dominik, MARTIN, Gilles-Antoine, SCHEIDT, Martin Maximilian, SIRENA, Dominique Nicolas, SCHÄFER, Caspar Ludwig Hermann, MÜLLER, Markus Daniel, NOVERRAZ, Marc Sylvain, BASCOUL, Denis Louis Raymond, BRAUN, Martin Edward, THOMAS, Helen Heide Erika, BREUER, Maximilian
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a process for the production of purified O-polysaccharide-Exoprotein A (O-EPA) bioconjugates. In particular, the process comprises a purification of said bioconjugate comprising the steps of a first anion exchange chromatography prior to a hydroxyapatite chromatography followed by a hydrophobic interaction chromatography and subsequently a second anion exchange chromatography.