SEPARATION COLUMN CONNECTION DEVICE AND SEPARATION DEVICE

Provided is a technique that facilitates replacement of a separation column. A separation column connection device of the disclosure includes: a driving device that supports a first pipe along a first direction and moves the first pipe in the first direction; a fixing member that fixes a second pipe so as to be opposed to the first pipe along the first direction; a column case arranged between the first pipe and the second pipe, the column case having a first hole with which the first pipe communicates and a second hole with which the second pipe communicates; and an interlocking mechanism that moves the column case in the first direction in conjunction with movement of the first pipe. The column case allows a column cartridge retaining a separation column to be connected and disconnected. The driving device moves the first pipe and the interlocking mechanism such that two states are reversibly taken, the two states including a closed state in which the separation column is pressurized and sandwiched between the first pipe and the second pipe and an open state in which the first pipe and the second pipe are positioned at an outer side of the column case.