AZOLO COMPOUNDS FOR TREATMENT OF FIBROTIC DISEASES

The present invention relates to an azolo compound of Formula Ifor use in the treatment of fibrosis, wherein the azolo compounds normalizes collagen I mRNA-levels of TGFβ-activated fibroblasts and reverses collagen production to the normal levels that are seen in fibroblasts that are not stimulated....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	VOSS, Edgar, HASENFUSS, Gerd, NYAMSUREN, Gunsmaa, TIETZE, Lutz Friedjahn, MOTHUKU, Shyam Sundar, ZEISBERG, Michael
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to an azolo compound of Formula Ifor use in the treatment of fibrosis, wherein the azolo compounds normalizes collagen I mRNA-levels of TGFβ-activated fibroblasts and reverses collagen production to the normal levels that are seen in fibroblasts that are not stimulated.