COMBINATION OF DEOXYRIBONUCLEASE ENZYME AND CELL THERAPIES FOR TREATMENT OF CANCER

COMBINATION OF DEOXYRIBONUCLEASE ENZYME AND CELL THERAPIES FOR TREATMENT OF CANCER

The invention relates to methods for treatment of cancers utilizing a combination of a deoxyribonuclease enzyme and adoptive cell immunotherapy comprising cells expressing a chimeric antigen receptor (CAR) or a T cell receptor (TCR). In particular embodiments, the deoxyribonuclease enzyme can be giv...

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Bibliographische Detailangaben
Hauptverfasser: STEPANOV, Alexey Vyacheslavovich, GENKIN, Dmitry Dmitrievich, TETS, Georgy Viktorovich, TETS, Viktor Veniaminovich
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention relates to methods for treatment of cancers utilizing a combination of a deoxyribonuclease enzyme and adoptive cell immunotherapy comprising cells expressing a chimeric antigen receptor (CAR) or a T cell receptor (TCR). In particular embodiments, the deoxyribonuclease enzyme can be given parenterally or encoded by a vector or secreted by a cell comprising TCR or CAR.