NOVEL PROTEIN PORES

The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	VAN DER VERREN, Sander Egbert, SINGH, Pratik Raj, JORDAN, Michael Robert, KILGOUR, John Joseph, REMAUT, Han, VAN GERVEN, Nani, JAYASINGHE, Lakmal Nishantha, HAMBLEY, Richard George, WALLACE, Elizabeth Jayne
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES
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Beschreibung
Zusammenfassung:	The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.