RECOMBINANT BACTERIUM AND USES THEREOF

The invention relates to a recombinant bacterium and uses thereof. In particular, it relates to the use of recombinant bacteria to translocate cargo proteins into the cytosol of target cells. Said recombinant bacteria comprises a T3 secretion system under the control of a genetic regulatory circuit...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ASENSIO CALAVIA, Alejandro, ÁLVAREZ GONZÁLEZ, Beatriz, FERNÁNDEZ HERRERO, Luis Ángel
Format: Patent
Sprache:eng ; fre ; ger
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Beschreibung
Zusammenfassung:The invention relates to a recombinant bacterium and uses thereof. In particular, it relates to the use of recombinant bacteria to translocate cargo proteins into the cytosol of target cells. Said recombinant bacteria comprises a T3 secretion system under the control of a genetic regulatory circuit and a targeting module which allow the recombinant bacteria to target specific cells, adhere to these and inject their cargo into the cytosol of the target cells.