TUMOR-SPECIFIC CLAUDIN 18.2 ANTIBODY-DRUG CONJUGATES

TUMOR-SPECIFIC CLAUDIN 18.2 ANTIBODY-DRUG CONJUGATES

The invention provides an ADC based on an antibody binding to CLDN18.2, wherein the antibody or fragment thereof exhibits increased binding to tumor tissue expressing CLDN18.2 over healthy tissue expressing CLDN18.2.

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Bibliographische Detailangaben
Hauptverfasser: VALENTOVA, Iva, BAMMERT, Lukas, WALDMEIER, Lorenz, HOSKOVA, Simona, BEERLI, Roger, MOEBIUS, Ulrich, KYRYCH SADILKOVA, Lenka
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention provides an ADC based on an antibody binding to CLDN18.2, wherein the antibody or fragment thereof exhibits increased binding to tumor tissue expressing CLDN18.2 over healthy tissue expressing CLDN18.2.