HIGH CONCENTRATION ANTI-ASS PROTOFIBRIL ANTIBODY FORMULATIONS AND METHODS OF USE THEREOF

HIGH CONCENTRATION ANTI-ASS PROTOFIBRIL ANTIBODY FORMULATIONS AND METHODS OF USE THEREOF

Provided herein are aqueous pharmaceutical formulations comprising high concentrations of an isolated anti-Aβ protofibril antibody or a fragment thereof that binds to human Aβ protofibrils, such as BAN2401, arginine, polysorbate 80, and a pharmaceutically acceptable buffer.

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Bibliographische Detailangaben
Hauptverfasser: Sakaguchi, Takahisa, Hsu, Yung Yueh, Ozawa, Takahiro, Kito, Hirokazu, Joshi, Anjali, Souillac, Pierre, Sakuramoto, Naomi, Yoshida, Nobuo
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Provided herein are aqueous pharmaceutical formulations comprising high concentrations of an isolated anti-Aβ protofibril antibody or a fragment thereof that binds to human Aβ protofibrils, such as BAN2401, arginine, polysorbate 80, and a pharmaceutically acceptable buffer.