METHODS AND COMPOSITIONS COMPRISING CATIONIC LIPIDS FOR IMMUNOTHERAPY BY DIRECT TUMOR INJECTION

METHODS AND COMPOSITIONS COMPRISING CATIONIC LIPIDS FOR IMMUNOTHERAPY BY DIRECT TUMOR INJECTION

Provided herein are novel immunotherapeutic interventions comprising the use of cationic lipid-based compositions for direct tumor injection. The compositions are effective for reducing, eliminating and/or preventing tumor growth and cancer proliferation with local, targeted, systemic and distal eff...

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Bibliographische Detailangaben
Hauptverfasser: GANDHAPUDI, Siva, K, WOODWARD, Jerold, CONN, Gregory, WARD, Martin, BEDU-ADDO, Frank
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Provided herein are novel immunotherapeutic interventions comprising the use of cationic lipid-based compositions for direct tumor injection. The compositions are effective for reducing, eliminating and/or preventing tumor growth and cancer proliferation with local, targeted, systemic and distal effectiveness. The compositions may comprise one or more cationic lipids such as DOTAP and DOTMA, and may further comprise additional components such as antigens, therapeutic agents and/or pharmaceutically acceptable excipients.