MULTIFUNCTIONAL CYCLIC DINUCLEOTIDE AND USE THEREOF

The present invention relates to a multifunctional cyclic-dinucleotide compound of formula (X) and its derivatives, which can be used as a prodrug of an apoptosis inducer or a cytotoxic agent for inducing cell apoptosis or anti-virus, and can also regulate immunity pathway to generate a therapeutica...

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Bibliographische Detailangaben
Hauptverfasser:	ZHANG, Tony Yantao, LV, Fei, QU, Li, ZHENG, Puji, LOU, Liang
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	The present invention relates to a multifunctional cyclic-dinucleotide compound of formula (X) and its derivatives, which can be used as a prodrug of an apoptosis inducer or a cytotoxic agent for inducing cell apoptosis or anti-virus, and can also regulate immunity pathway to generate a therapeutically beneficial immune response. The present disclosure further relates to pharmaceutical compositions and pharmaceutical combinations comprising the cyclic-dinucleotide compounds of the present invention, methods for synthesizing them, and medical uses thereof.